Monika Paroder and Nancy Carrasco Juan Pablo Nicola , Cécile Basquin , Carla Portulano , Andrea Reyna - Neyra , the intestine The Na + / I - symporter mediates active iodide uptake in
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The Na+/I- symporter mediates active iodide uptake in the intestine.
Absorption of dietary iodide, presumably in the small intestine, is the first step in iodide (I(-)) utilization. From the bloodstream, I(-) is actively taken up via the Na(+)/I(-) symporter (NIS) in the thyroid for thyroid hormone biosynthesis and in such other tissues as lactating breast, which supplies I(-) to the newborn in the milk. The molecular basis for intestinal I(-) absorption is unkn...
متن کاملMechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS).
I(-) uptake in the thyroid, the first step in thyroid hormone biosynthesis, is mediated by the Na(+)/I(-) symporter (NIS) with an electrogenic 2Na(+):1I(-) stoichiometry. We have obtained mechanistic information on NIS by characterizing the congenital I(-) transport defect-causing NIS mutant G93R. This mutant is targeted to the plasma membrane but is inactive. Substitutions at position 93 show ...
متن کاملThe Na+/I- symporter (NIS): mechanism and medical impact.
The Na(+)/I(-) symporter (NIS) is the plasma membrane glycoprotein that mediates active I(-) transport in the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. In the thyroid, NIS-mediated I(-) uptake plays a key role as the first step in the biosynthesis of the thyroid hormones, of which iodine is an essential constituent. These hormones are cr...
متن کاملThe Iodide Transport Defect - Causing Mutation R 124 H : a 3 δ - amino group at position 124 is critical for maturation 4 and trafficking of the Na + / I - symporter ( NIS )
7 Viktoriya Paroder, Juan P. Nicola, Christopher S. Ginter, 8 and Nancy Carrasco 9 10 a Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461. 11 b Department of Cellular and Molecular Physiology, Yale University School of Medicine, New 12 Haven, CT 06510. 13 14 Present addresses: 1 Department of Radiology, Montefiore Medical Center. Bronx, NY 10467. 2 15 De...
متن کاملExpression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus
Expression of the Na+/Isymporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus BMC Cancer 2007, 7:5 doi:10.1186/1471-2407-7-5 Aron Altorjay ([email protected]) Orsolya Dohan ([email protected]) Anna Szilagyi ([email protected]) Monika Paroder ([email protected]) Irene L Wapnir ([email protected]) Nancy Carrasc...
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